Melissa Kaplan's
Chronic Neuroimmune Diseases
Information on CFS, FM, MCS, Lyme Disease, Thyroid, and more...
Last updated January 1, 2014

Heart Rate Variability Associated with Particulate Air Pollution

C. Arden Pope III et al., Am Heart J 138(5):890-899, 1999

C. Arden Pope III, PhD, Richard L. Verrier, PhD, Eric G. Lovett, PhD, Andrew C. Larson, BS, Mark E. Raizenne, BA, BSc, Richard E. Kanner, MD, Joel Schwartz, PhD, G. Martin Villegas, BS, Diane R. Gold, MD, Douglas W. Dockery, ScD

Brigham Young University, Provo, Utah; Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass; Marquette Medical Systems, Milwaukee, Wis; Health Canada, Ottawa, Ontario, Canada; University of Utah School of Medicine, Salt Lake City, Utah; Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, and Harvard School of Public Health, Boston, Mass.

Am Heart J 138(5):890-899, 1999
Printable Full Text Version with Charts/Illustrations

Background:
Epidemiologic studies have linked fine particulate air pollution with cardiopulmonary mortality, yet underlying biologic mechanisms remain unknown. Changes in heart rate variability (HRV) may reflect changes in cardiac autonomic function and risk of sudden cardiac death. This study evaluated changes in mean heart rate and HRV in human beings associated with changes in exposure to particulate air pollution.

Methods:
Repeated ambulatory electrocardiographic monitoring was conducted on 7 subjects for a total of 29 person-days before, during, and after episodes of elevated pollution. Mean HR, the standard deviation of normal-to-normal (NN) intervals (SDNN), the standard deviation of the averages of NN intervals in all 5-minute segments of the recording (SDANN), and the square root of the mean of squared differences between adjacent NN intervals (r-MSSD) were calculated for 24-hour and 6-hour time segments. Associations of HRV with particulate pollution levels were evaluated with fixed-effects regression models.

Results:
After controlling for differences across patients, elevated particulate levels were associated with (1) increased mean HR, (2) decreased SDNN, a measure of overall HRV, (3) decreased SDANN, a measure that corresponds to ultralow frequency variability, and (4) increased r-MSSD, a measure that corresponds to high-frequency variability. The associations between HRV and particulates were small but persisted even after controlling for mean HR.

Conclusions:
This study suggests that changes in cardiac autonomic function reflected by changes in mean HR and HRV may be part of the pathophysiologic mechanisms or pathways linking cardiovascular mortality and particulate air pollution.

 

http://www.anapsid.org/cnd/mcs/heartpollute.html

Activism

Disability

Pain

About Melissa Kaplan

Books

Drugs

Pets

Herp Care

Chemical Sensitivity

Finding Support/Doctors/Attorneys

Resources

Green Iguana Care
CopingGenderThyroidHelp Support This Site
DiagnosisHormonesCND HomeAdvance Care Directives
Differential DxLyme DiseaseAnapsid HomeEmergency Preparedness

 

© 1994-2014 Melissa Kaplan or as otherwise noted by other authors of articles on this site

Powered by Veterinary Information Network, Inc.