Sources and Recommended Dosages for CFS
Compiled by Melissa Kaplan
Cheney MD (Balance the Th1/Th2 Immune
System) and other CFS doctors recommend their patients take a product
called Immunovir. Immunovir is not only very expensive, but it has to be
ordered from Ireland, so it takes a while to get it.
Immunovir is isoprinosine. Outside of the United States, it is also sold as Inosine Pranobex, and Inosine.
There is no area/city code for Costa Rica so you may not need to dial the 00
Extension Foundation - Inosine
Take the same quantity of Inosine as Immunovir/Isoprinosine. If you will be buying other products from LEF, it may well be worth it to become a member in order to obtain member discounts.
What is Isoprinosine?
Where is it found?
Who is likely to
How much is usually
Are there any side
effects or interactions?
To store this medicine:
Those with gout or a predisposition to develop gout should not use Isoprinosine.
Other Possible Side
1. Starling RD, Trappe TA, Short KR, et al. Effect of inosine supplementation on aerobic and anaerobic cycling performance. Med Sci Sports Ex 1996;28(9):1193-98.
2. Williams MH, Kreider RB, Hunter DW, et al. Effect of inosine supplementation on 3-mile treadmill run performance and VO2 peak. Med Sci Sports Exerc 1990 Aug;22(4):517-22.
There is no way to know what the proper dose is. However the clinical studies thus far have examined between 1 - 4 grams per day. The Danish study used 1 gram three times a day. The tablets we distribute are 500 MG each. To take the doses used in the studies, you would take between 2 and 8 tablets every day. To our knowledge, only one study has evaluated how isoprinosine is absorbed and excreted in humans. This study demonstrated that isoprinosine doesn't stay in the body very long. To keep consistent levels of isoprinosine in the body would require fairly frequent oral doses, three or more times a day. Taking isoprinosine as an injection or an enema may deliver initially higher doses into the blood, but the body eliminates this isoprinosine just as quickly. We don't know whether the body requires consistent levels of an immune modulator in order to respond to it, but if it does, oral dosing is the easiest way to achieve this.
CFIDS doctor Paul Cheney MD recommends the following dosing and frequency of isoprinosine for Th1/Th2 dysregulation:
Month 2: Repeat
According to Cheney, this medicine works best when you use this "pulsing" treatment of two months on, one month off, and the different amounts each week during the months that you are taking it, rather than taking it at the same dose all through the "on" months, or at the same dose continuously for six months. It may be that all immune modulators work like this, working better and for longer periods of time when they are pulsed.
Byron Hyde, MD, has a preliminary report on isoprinosine at his Nightingale Foundation site.
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